BIOHEDRON Therapeutics

Contect
biohedron@gmail.com

Research Method & Tool Development
- Passive Tissue Clearing Technique
- Tissue & Cell Expansion Technique

‌- In vivo & In Vitro Cell-based Assay

Imaging Technique
- Super-resolution Imaging Analysis
- Biological Network Analysis

Drug Discovery
- Anti-viral Drug
- Pandemic Disease (Influenza Virus, SARS-CoV, MERS-CoV, and Zika Virus, and so on)
- Viral Packaging Inhibition





Astro Biology (Astro Microbiology)
- Mysterious Microorganism (Exo) in Earth and Space, or Under Space Conditions

 Research

BIOHEDRON Therapeutics


Publications

- Lee M*, Woo J*, Kim KT, Moon SA, Park HC, Kim TY, Park JY. Customized Hydrogel Films for MicroRNA Super-Resolution Imaging in Liquid Biopsies. Adv Healthc Mater. 2024 Sep;13(22):e2303781.

- Jin BH*, Woo J*, Lee M, Ku S, Moon HS, Ryu SJ, Hyun YM, Park JY, Kuh SU, Cho YE. Optimization of the optical transparency of bones by PACT-based passive tissue clearing. Exp Mol Med. 2023 Oct;55(10):2190-2204.

-  Woo J, Lee EY, Lee M, Ku S, Park JY, Cho YE. Comparative Analyses of Clearing Efficacies of Tissue Clearing Protocols by Using a Punching Assisted Clarity Analysis. Front Bioeng Biotechnol. 2022 Jan 28;9:784626.

- Lee M*, Woo J*, Kim DH*, Yang YM, Lee EY, Kim JH, Kang SG, Shim JK, Park JY. A novel paper MAP method for rapid high resolution histological analysis. Sci Rep. 2021 Dec 2;11(1):23340.

- Woo J*, Jin BH*, Lee M, Lee EY, Moon HS, Park JY, Cho YE. Investigation of PRDM10 and PRDM13 Expression in Developing Mouse Embryos by an Optimized PACT-Based Embryo Clearing Method. Int J Mol Sci. 2021 Mar 12;22(6):2892.

- Woo J*, Seo JM*, Lee M, Kim J, Min S, Kim ST, Ku S, Park JY. A Modified Magnified Analysis of Proteome (MAP) Method for Super-Resolution Cell Imaging that Retains Fluorescence. Sci Rep. 2020 Mar 6;10(1):4186.

- Woo J*, Kang H*, Lee EY, Park S, Cho YE. Investigation of PRDM7 and PRDM12 expression pattern during mouse embryonic development by using a modified passive clearing technique. Biochem Biophys Res Commun. 2020 Apr 2;524(2):346-353.

- Woo J, Lee EY, Park HS, Park JY, Cho YE. Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue. J Vis Exp. 2018 May 8;(135):57123.

- Woo J, Lee M, Seo JM, Park HS, Cho YE. Optimization of the optical transparency of rodent tissues by modified PACT-based passive clearing. Exp Mol Med. 2016 Dec 2;48(12):e274.

- Woo J, Lee EY, Lee M, Kim T, Cho YE. An in vivo cell-based assay for investigating the specific interaction between the SARS-CoV N-protein and its viral RNA packaging sequence. Biochem Biophys Res Commun. 2019 Dec 10;520(3):499-506.

- Woo J, Yu KL, Lee SH, You JC. Development of a functional cell-based assay that probes the specific interaction between influenza A virus NP and its packaging signal sequence RNA. Biochem Biophys Res Commun. 2015 Feb 6;457(2):227-33.

Patents


- Woo J, Park JY, Lee CK. A High-Efficiency Tissue Clearing Composition Comprising a Water-Soluble Alcohol, and a Tissue Clearing Method Employing the Same. KR-PN: Coming Soon.

- Woo J, Park JY. Cell film for high magnification analysis of cell expansion, composition and method for preparing the same. PCT-PN: PCT/KR2023/014689.

- Woo J, Park JY, Lee M. Cell film for high magnification analysis of cell expansion, composition and method for preparing the same. KR-PN: 10-2022-0121707.

-  Woo J, Park JY, Cho YE, Jim BY. Tissue Clearing Mixture for Anti-swelling of Hydrogel Tissue. KR-PN: 10-2022-0118214, KR-AN: Coming Soon.

- Woo J, Cho YE. Tissue Clarity Measurement Assay. KR-PN: 10-2017-0184244, KR-AN: 10-2050248.